xanthine dehydrogenase การใช้

• It is degraded by xanthine dehydrogenase to 2, 8-dihydroxyadenine ( DHA ).
• Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification.
• Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines.
• MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase ( XDH ) and aldehyde oxidase ( AOX1 ), which is required for their enzymatic activities.
• CPMP is a precursor to molybdenum cofactor, which is required for the enzyme activity of sulfite oxidase, xanthine dehydrogenase / oxidase and aldehyde oxidase.
• Ethanol also increases the plasma concentrations of hypoxanthine and xanthine via the acceleration of adenine nucleotide degradation, and is a possible weak inhibitor of xanthine dehydrogenase.
• Most of the protein in the liver exists in a form with xanthine dehydrogenase activity, but it can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification.
• The same protein, which in humans has the HGNC approved gene symbol " XDH ", can also have xanthine dehydrogenase activity ( EC 1.17.1 . 4 ).
• It is treatable with regular doses of allopurinol or febuxostat, which inhibit xanthine dehydrogenase activity to prevent the accumulation and precipitation of DHA . The condition can also be attenuated with a low-purine diet and high fluid intake.
• The eukaryotic molybdopterin binding domain is currently found in only five other human genes, xanthine dehydrogenase, sulfite oxidase ( mitochondrial precursor ), aldehyde oxidase, erythropoietin receptor precursor and the ATPbinding cassette, sub-family A, member 2 ( ABCA2 ).
• Although a tungsten-containing xanthine dehydrogenase from bacteria has been found to contain tungsten-molydopterin and " also " non-protein-bound selenium ( thus removing the possibility of selenium in selenocysteine or selenomethionine form ), a tungsten-selenium molybdopterin complex has not been definitively described.